Rh(II)/Pd(0) Dual Catalysis: Carbenoid N-H Insertion/Allylation Cascade Reaction to Construct Highly Functionalized and Polysubstituted Pyrrolidines

Rh(II)/Pd(0) Dual Catalysis: Carbenoid N-H Insertion/Allylation Cascade Reaction to Construct Highly Functionalized and Polysubstituted Pyrrolidines

In the category of drugs approved by the U.S. FDA, pyrrolidine is the most frequently used core of five-membered nonaromatic heterocycles containing nitrogen. Herein, a Rh(II)/Pd(0) dual-catalyzed carbenoid N-H insertion/allylation cascade reaction has been developed. This protocol provide an effici...

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Bibliographic Details
Main Authors: Maocheng Tang, Xianyan Jiao, Deping He, Ji-Xing Zhao, Ping Liu, Chun-Tian Li
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
pyrrolidines
carbenoid N-H insertion
allylation
Rh(II)/Pd(0) dual catalysis
high diastereoselectivities
Online Access:https://www.mdpi.com/1420-3049/29/24/5880
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