Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses

Ligand‐dependent responses of the ErbB signaling network: experimental and modeling analyses

Abstract Deregulation of ErbB signaling plays a key role in the progression of multiple human cancers. To help understand ErbB signaling quantitatively, in this work we combine traditional experiments with computational modeling, building a model that describes how stimulation of all four ErbB recep...

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Bibliographic Details
Main Authors: Marc R Birtwistle, Mariko Hatakeyama, Noriko Yumoto, Babatunde A Ogunnaike, Jan B Hoek, Boris N Kholodenko
Format: Article
Language:English
Published: Springer Nature 2007-11-01
Series:Molecular Systems Biology
Subjects:
breast cancer
kinetic analysis
mathematical modeling
receptor tyrosine kinases
Online Access:https://doi.org/10.1038/msb4100188
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https://doi.org/10.1038/msb4100188

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