Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Separate signaling events control TCR downregulation and T cell activation in primary human T cells

Abstract Introduction T‐cell antigen receptor (TCR) interaction with cognate peptide:MHC complexes trigger clustering of TCR:CD3 complexes and signal transduction. Triggered TCR:CD3 complexes are rapidly internalized and degraded in a process called ligand‐induced TCR downregulation. Classic studies...

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Bibliographic Details
Main Authors: Lieve E. H. van derDonk, Louis S. Ates, Jet van derSpek, Laura M. Tukker, Teunis B. H. Geijtenbeek, Jeroen W. J. vanHeijst
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Immunity, Inflammation and Disease
Subjects:
CD4+ T cells
protein tyrosine kinases
T‐cell activation | T‐cell receptor
TCR downregulation
Online Access:https://doi.org/10.1002/iid3.383
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https://doi.org/10.1002/iid3.383

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