Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine and the Related Natural Products Norketoyobyrine and Naucleficine

Total Synthesis and Biological Evaluation of 22-Hydroxyacuminatine and the Related Natural Products Norketoyobyrine and Naucleficine

Aromathecin compounds—which contain the same indolizine core structure as camptothecin-like compounds—are expected to show anticancer activity. Among them, 22-hydroxyacuminatine—which has a substituent on the E-ring of the pentacyclic scaffold—exhibits topoisomerase 1 inhibitory activity; therefore,...

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Bibliographic Details
Main Authors: Shohta Mizuno, Takashi Nishiyama, Hana Bessho, Tetsuya Nakamura, Tomoki Oe, Nanako Hayashi, Yuhzo Hieda, Toshio Motoyashiki, Toshiyuki Hata, Noriyuki Hatae, Tominari Choshi
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Molecules
Subjects:
total synthesis
22-hydroxyacuminatine
norketoyobyrine
naucleficine
antiproliferative activity
Online Access:https://www.mdpi.com/1420-3049/30/12/2650
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