Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca2+ channel may modulate its β-adrenergic regulation

Abstract Background The β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated CaV1.2 channels, is of great physiological and pathophysiological importance. Stimulation of β-adrenergic receptors (βAR) activates protein kinase A (PKA) through separati...

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Main Authors: Shimrit Oz, Tal Keren-Raifman, Tom Sharon, Suraj Subramaniam, Tamara Pallien, Moshe Katz, Vladimir Tsemakhovich, Anastasiia Sholokh, Baraa Watad, Debi Ranjan Tripathy, Giorgia Sasson, Orna Chomsky-Hecht, Leonid Vysochek, Maike Schulz-Christian, Claudia Fecher-Trost, Kerstin Zühlke, Daniela Bertinetti, Friedrich W. Herberg, Veit Flockerzi, Joel A. Hirsch, Enno Klussmann, Sharon Weiss, Nathan Dascal
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Biology
Subjects:
Calcium channel
Protein‐protein interaction
Adrenergic regulation
Cardiac
Protein kinase A (PKA)
Heterologous expression
Online Access:https://doi.org/10.1186/s12915-024-02076-9
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https://doi.org/10.1186/s12915-024-02076-9

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