Association of HER2 amplification or overexpression with overall survival in advanced upper gastrointestinal adenocarcinomas

Association of HER2 amplification or overexpression with overall survival in advanced upper gastrointestinal adenocarcinomas

Abstract Background Advanced esophageal (EAC), gastroesophageal junction (GEJAC) and gastric (GAC) adenocarcinomas with HER2 amplification or overexpression (HER2+) are routinely treated with trastuzumab. However, it remains unclear if HER2+ is associated with superior overall survival (OS). Methods...

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Main Authors: Minggui Pan, Arun Dang, Tina Huang, Jack Stover, Meng M. Tong, Chen Jiang, Ninah S. Achacoso, Jeffrey Bien, Aleyda V. Solorzano, Pamela Tse, Elaine Chung, Vishnu P. Kanakaveti, Dean Felsher, George A. Fisher, Sachdev Thomas, Laurel Habel
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:BJC Reports
Online Access:https://doi.org/10.1038/s44276-025-00148-z
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https://doi.org/10.1038/s44276-025-00148-z

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