Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma

Coordinating oncogenesis and immune evasion: KPNA2, GOLM1, and TK1 as novel CAR T-cell targets in lung adenocarcinoma

Abstract Although immune checkpoint inhibitors (ICIs) hold promise for those diagnosed with advanced human lung adenocarcinoma (LUAD), notable heterogeneity in patient responses and the complex tumor microenvironment (TME) limits their clinical utility while providing clinical benefit. To identify n...

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Bibliographic Details
Main Authors: Wangrui Liu, Hui Zou, Lei Guo, Zhonghua Zhou, Yahui Xie, Huaqi Guo, Gang Wei, Kai Zhang, Hui Yin, Shiyin Wei, Jiachang Chi
Format: Article
Language:English
Published: BMC 2025-08-01
Series:European Journal of Medical Research
Subjects:
Tumor microenvironment
CAR-T therapy
Lung cancer
Online Access:https://doi.org/10.1186/s40001-025-02955-z
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https://doi.org/10.1186/s40001-025-02955-z

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