Treating nightmares in post-traumatic stress disorder with the α-adrenergic agents clonidine and doxazosin: protocol for a phase II randomised, double-blind, placebo-controlled parallel-group study (ClonDoTrial)

Treating nightmares in post-traumatic stress disorder with the α-adrenergic agents clonidine and doxazosin: protocol for a phase II randomised, double-blind, placebo-controlled parallel-group study (ClonDoTrial)

Introduction Intrusive nightmares are a hallmark symptom of post-traumatic stress disorder (PTSD), contributing significantly to psychiatric comorbidities, impaired physical health and diminished social functioning. Currently, no pharmacological treatments are specifically approved for managing PTSD...

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Main Authors: Christian Schmahl, Jürgen Gallinat, Andreas J Fallgatter, Christian Otte, Stefan Roepke, Robert Roehle, Nikola Schoofs, Kathlen Priebe, Felix Wuelfing, Tolou Maslahati, Katharina Stieglbauer, Sarah Biedermann, Ingo Schaefer, Thomas Ethofer, Bernd Hanewald, Christoph Mulert, Stefanie Koglin
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e098161.full
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https://bmjopen.bmj.com/content/15/8/e098161.full

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