Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin

Ex vivo gene delivery to the skin utilizing retroviral vectors has been demonstrated to be a viable clinical option for replacement of defective genes. However, because these vectors integrate their cargo into the genome, safety issues arise when utilizing them to deliver gene-editing nucleases. Her...

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Bibliographic Details
Main Authors: Francesco Diversi, Juliette Dabin, Elisa Mazza, Mirko Rinaldin, Fernanda de Castro Reis, Jamie A. Hackett, Paul A. Heppenstall
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
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Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125000551
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