In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection

In vivo efficacy of a refillable intrawound drug delivery device in a sheep model of biofilm-compromised open fracture-related infection

Open fracture-related infection challenges persist in healthcare. From the time open fractures were defined ∼50 years ago, infection rates have gone essentially unchanged. Contributing factors include compromised vasculature, biofilm, and stalled innovations in treatment and prophylaxis. In this stu...

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Bibliographic Details
Main Authors: Dustin Williams, David Rothberg, Walker Kay, Lisa Nehring, Robert Falconer, Richard Tyler Epperson, Brooke Kawaguchi, Carolyn Ardizzone, Brian Barnum, Nicholas Ashton
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Biofilm
Subjects:
Open fracture
Infection
Biofilm
Orthopedic
Sustainable drug delivery
Sheep model
Online Access:http://www.sciencedirect.com/science/article/pii/S2590207525000103
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