Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a severe inflammatory condition that remains refractory; however, its molecular mechanisms are largely unknown. Previous studies have shown numerous compounds containing 4-indolyl-2-aminopyrimidine that display strong ant...

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Main Authors: Shiyi Yang, Kaijun Chen, Jinkang Yu, Zhangchu Jin, Min Zhang, Zhouyang Li, Yang Yu, Nanxia Xuan, Baoping Tian, Na Li, Zhengtong Mao, Wenbing Wang, Tianpeng Chen, Yinfang Wu, Yun Zhao, Xia Fei, Songmin Ying, Wen Li, Fugui Yan, Xingxian Zhang, Gensheng Zhang, Huahao Shen, Zhihua Chen
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Molecular interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224022491
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