Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

Cingulin is an RNA-binding protein promoting pancreatic cancer through enhancing importin 7-mediated phospho-ERK nuclear translocation

Summary: Pancreatic ductal adenocarcinoma (PDAC), a lethal malignancy with difficult early diagnosis and poor prognosis, urgently requires elucidation of the molecular determinants dictating pancreatic cancer initiation and progression. Little is known about cingulin (CGN) in carcinogenesis. In this...

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Main Authors: Yuling Su, Fang Wei, Shu Li, Jiaming Qi, Guohuan Lin, Guantuo Li, Ping Liang, Zhenwei Yang, You Long, Xiaojia Li, Tingting Jiang, Jie He, Weiye Liang, Keping Xie
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725006965
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