Subtractive proteo-genomics and model-based druggability analyses prioritized nitrate reductase-A subunit-α as potential therapeutic target against MDR pneumonia; a homology-based approach

Subtractive proteo-genomics and model-based druggability analyses prioritized nitrate reductase-A subunit-α as potential therapeutic target against MDR pneumonia; a homology-based approach

Abstract Background Bacterial pneumonia is a severe respiratory infection that damages the lungs, representing one of the most serious public health problems worldwide due to its morbidity and mortality across all age groups. The challenge is further exacerbated by emergence of multidrug-resistant s...

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Main Authors: Kainat Begum, Sara Aiman, Asifullah Khan, Mah Noor Mumtaz, Fawad Ali, Shaik Althaf Hussain, Sara Khan, Mohammed Rafi Shaik
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Microbiology
Subjects:
Pneumonia
Comparative proteomics
Anti-pneumonia therapeutics
Multi-drug resistance
Drug designing and development
Online Access:https://doi.org/10.1186/s12866-025-03883-y
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https://doi.org/10.1186/s12866-025-03883-y

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