Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells

Platinum(IV) anticancer therapies and cathepsin B: innovative strategies for overcoming resistance in glioblastoma cells

Glioblastoma (GBM) is the most frequent and aggressive brain tumor in adults. Due to its heterogeneity, the abundance of altered signaling pathways within the same tumoral mass, its low immunogenicity, and the presence of the blood–brain barrier, standard therapies based on surgical resection, radio...

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Bibliographic Details
Main Authors: Claudio Casali, Ludovica Gaiaschi, Enrico Pelloni, Federica Gola, Margherita Cavallo, Gloria Milanesi, Mauro Ravera, Marco Biggiogera, Fabrizio De Luca, Maria Grazia Bottone
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
glioblastoma
cathepsin B
drug resistance
platinum(IV)
apoptosis
mitophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1506206/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1506206/full

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