Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration
Interior bone-tissue regeneration and rapid tumor recurrence post-resection are critical challenges in osteosarcoma and other bone cancers. Conventional bone tissue engineering scaffolds lack inhibitory effects on bone tumor recurrence. Herein, multifunctional scaffolds (named DOX/PDA@CDHA) were des...
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Elsevier
2024-12-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003144 |
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| author | Lu Wang Zihan Dai Jianqiang Bi Yunzhen Chen Ziyu Wang Zhenqian Sun Zhongjie Ji Hongliang Wang Yan Zhang Limei Wang Junjie Mao Junxing Yang |
| author_facet | Lu Wang Zihan Dai Jianqiang Bi Yunzhen Chen Ziyu Wang Zhenqian Sun Zhongjie Ji Hongliang Wang Yan Zhang Limei Wang Junjie Mao Junxing Yang |
| author_sort | Lu Wang |
| collection | DOAJ |
| description | Interior bone-tissue regeneration and rapid tumor recurrence post-resection are critical challenges in osteosarcoma and other bone cancers. Conventional bone tissue engineering scaffolds lack inhibitory effects on bone tumor recurrence. Herein, multifunctional scaffolds (named DOX/PDA@CDHA) were designed through the spontaneous polymerization of Dopamine (PDA) on the surface of Calcium Deficient Hydroxyapatite (CDHA) scaffolds, followed by in situ loading of the chemotherapeutic drug Doxorubicin (DOX). The PDA coating endowed the scaffolds with significant photothermal properties, while the gradual release of DOX provided an effective chemotherapeutic effect. The on-demand release of DOX at tumor sites, triggered by dual stimulation (near-infrared (NIR) light and the acidic pH typical of tumor microenvironments), specifically targets cancer cells, thereby mitigating systemic side effects. These unique characteristics facilitated effective osteosarcoma eradication both in vitro and in vivo. Moreover, the scaffold's composition, which mimics the mineral phase of natural bone and is enhanced by PDA's biocompatibility, promotes critical osteogenic and angiogenic processes. This facilitates not only tumor eradication but also the regeneration of healthy bone tissue. Collectively, this study presents a potent candidate for the regeneration of bone defects induced by osteosarcoma. |
| format | Article |
| id | doaj-art-5291a160aae745129a79d6fae5df33d3 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-5291a160aae745129a79d6fae5df33d32025-08-20T02:37:39ZengElsevierMaterials Today Bio2590-00642024-12-012910125310.1016/j.mtbio.2024.101253Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regenerationLu Wang0Zihan Dai1Jianqiang Bi2Yunzhen Chen3Ziyu Wang4Zhenqian Sun5Zhongjie Ji6Hongliang Wang7Yan Zhang8Limei Wang9Junjie Mao10Junxing Yang11Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan, 250061, PR China; Schools of Materials Science and Engineering, Shandong University, Jinan, 250061, PR ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhuaxi Road, Jinan, 250061, PR China; Cheeloo College of Medicine, Shandong University, Jinan, 250061, PR ChinaKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan, 250061, PR China; Schools of Materials Science and Engineering, Shandong University, Jinan, 250061, PR China; Corresponding author. Schools of Materials Science and Engineering, Shandong University, Jinan, 250061, PR China.Department of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhuaxi Road, Jinan, 250061, PR China; Corresponding author.Department of Orthopaedics, Peking University Third Hospital, Beijing, 100191, PR ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhuaxi Road, Jinan, 250061, PR China; Cheeloo College of Medicine, Shandong University, Jinan, 250061, PR ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhuaxi Road, Jinan, 250061, PR China; Cheeloo College of Medicine, Shandong University, Jinan, 250061, PR ChinaDepartment of Orthopedics, Qilu Hospital of Shandong University, #107 Wenhuaxi Road, Jinan, 250061, PR China; Cheeloo College of Medicine, Shandong University, Jinan, 250061, PR ChinaAdvanced Medical Research Institute/Translational Medicine Core Facility of Advanced Medical Research Institute, Shandong University, PR ChinaAdvanced Medical Research Institute/Translational Medicine Core Facility of Advanced Medical Research Institute, Shandong University, PR ChinaKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan, 250061, PR China; Schools of Materials Science and Engineering, Shandong University, Jinan, 250061, PR ChinaKey Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan, 250061, PR China; Schools of Materials Science and Engineering, Shandong University, Jinan, 250061, PR ChinaInterior bone-tissue regeneration and rapid tumor recurrence post-resection are critical challenges in osteosarcoma and other bone cancers. Conventional bone tissue engineering scaffolds lack inhibitory effects on bone tumor recurrence. Herein, multifunctional scaffolds (named DOX/PDA@CDHA) were designed through the spontaneous polymerization of Dopamine (PDA) on the surface of Calcium Deficient Hydroxyapatite (CDHA) scaffolds, followed by in situ loading of the chemotherapeutic drug Doxorubicin (DOX). The PDA coating endowed the scaffolds with significant photothermal properties, while the gradual release of DOX provided an effective chemotherapeutic effect. The on-demand release of DOX at tumor sites, triggered by dual stimulation (near-infrared (NIR) light and the acidic pH typical of tumor microenvironments), specifically targets cancer cells, thereby mitigating systemic side effects. These unique characteristics facilitated effective osteosarcoma eradication both in vitro and in vivo. Moreover, the scaffold's composition, which mimics the mineral phase of natural bone and is enhanced by PDA's biocompatibility, promotes critical osteogenic and angiogenic processes. This facilitates not only tumor eradication but also the regeneration of healthy bone tissue. Collectively, this study presents a potent candidate for the regeneration of bone defects induced by osteosarcoma.http://www.sciencedirect.com/science/article/pii/S2590006424003144Calcium-deficient hydroxyapatitePolydopamineDoxorubicinAntitumorPhotothermal/chemotherapyBone regeneration |
| spellingShingle | Lu Wang Zihan Dai Jianqiang Bi Yunzhen Chen Ziyu Wang Zhenqian Sun Zhongjie Ji Hongliang Wang Yan Zhang Limei Wang Junjie Mao Junxing Yang Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration Materials Today Bio Calcium-deficient hydroxyapatite Polydopamine Doxorubicin Antitumor Photothermal/chemotherapy Bone regeneration |
| title | Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration |
| title_full | Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration |
| title_fullStr | Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration |
| title_full_unstemmed | Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration |
| title_short | Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration |
| title_sort | polydopamine functionalized calcium deficient hydroxyapatite 3d printed scaffold with sustained doxorubicin release for synergistic chemo photothermal therapy of osteosarcoma and accelerated bone regeneration |
| topic | Calcium-deficient hydroxyapatite Polydopamine Doxorubicin Antitumor Photothermal/chemotherapy Bone regeneration |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003144 |
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