Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration

Polydopamine-functionalized calcium-deficient hydroxyapatite 3D-printed scaffold with sustained doxorubicin release for synergistic chemo-photothermal therapy of osteosarcoma and accelerated bone regeneration

Interior bone-tissue regeneration and rapid tumor recurrence post-resection are critical challenges in osteosarcoma and other bone cancers. Conventional bone tissue engineering scaffolds lack inhibitory effects on bone tumor recurrence. Herein, multifunctional scaffolds (named DOX/PDA@CDHA) were des...

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Bibliographic Details
Main Authors: Lu Wang, Zihan Dai, Jianqiang Bi, Yunzhen Chen, Ziyu Wang, Zhenqian Sun, Zhongjie Ji, Hongliang Wang, Yan Zhang, Limei Wang, Junjie Mao, Junxing Yang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Materials Today Bio
Subjects:
Calcium-deficient hydroxyapatite
Polydopamine
Doxorubicin
Antitumor
Photothermal/chemotherapy
Bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006424003144
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