Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

Background: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines. The present study aimed to construct a synthetic antigen multi-epitope SARS-CoV-2 to produce...

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Main Authors: Maria da Conceição Viana Invenção, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos, Benigno Cristofer Flores Espinoza, Samara Sousa de Pinho, Lígia Rosa Sales Leal, Daffany Luana dos Santos, Bianca de França São Marcos, Carolina Elsztein, Georon Ferreira de Sousa, Guilherme Antonio de Souza-Silva, Bárbara Rafaela da Silva Barros, Leonardo Carvalho de Oliveira Cruz, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Cristiane Moutinho Lagos de Melo, Anna Jéssica Duarte Silva, Marcus Vinicius de Aragão Batista, Antonio Carlos de Freitas
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
vaccinology
immunoinformatics
variants
Online Access:https://www.mdpi.com/2076-393X/13/2/149
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