Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe
This study aims at identifying ocular findings in infants with microcephaly associated with presumed intrauterine infection by ZIKV. A cross-sectional study included 62 outpatient infants with congenital microcephaly, presumably secondary to maternal ZIKV infection. The included infants had head cir...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2020/7092432 |
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| author | Marco Valadares Anne Carolyne Lelis Oliveira Pedroso Alessandro Santana Angela Maria da Silva Isabela Soares Costa Maria Luiza Doria Almeida Roque Pacheco de Almeida |
| author_facet | Marco Valadares Anne Carolyne Lelis Oliveira Pedroso Alessandro Santana Angela Maria da Silva Isabela Soares Costa Maria Luiza Doria Almeida Roque Pacheco de Almeida |
| author_sort | Marco Valadares |
| collection | DOAJ |
| description | This study aims at identifying ocular findings in infants with microcephaly associated with presumed intrauterine infection by ZIKV. A cross-sectional study included 62 outpatient infants with congenital microcephaly, presumably secondary to maternal ZIKV infection. The included infants had head circumference below −2 standard deviations, with negative maternal serology for toxoplasmosis, rubella, cytomegalovirus, syphilis, and HIV. Assessment of ocular alterations was performed through review of their medical records. Forty two (67.7%) of the children analyzed presented some degree of ocular alteration. Findings in the posterior segment occurred in 29 (46.8%) patients, including atrophy of the retinal pigmentary epithelium in 15 (24.2%) patients, chorioretinal scars in 14 (22.6%) patients, retinal coloboma in 6 (9.7%) patients, and punctate retinal hemorrhage in 1 (1.6%) patient. Other ocular alterations were seen in 15 (24.2%) patients, including pathological strabismus in 11 (17.7%) patients, congenital cataracts in 2 (3.2%) patients, and nystagmus in 2 (3.2%) patients. Functional alterations were seen in four (6.5%) children. More than one change occurred in 11 (17.7%) children, eight of whom had head circumferences below −3 standard deviations. Changes in both the eyes occurred in 22 (35.5%) children, while 20 (32.3%) children had unilateral involvement. Among the 42 children with any ocular alteration, 27 (64.3%) children presented with severe microcephaly (head circumference with standard deviation lower than −3). The majority of children with microcephaly, presumably secondary to maternal ZIKV infection, present ocular alterations, with a higher frequency of involvement in the fundus. Severe ocular alterations are related to severe microcephaly. |
| format | Article |
| id | doaj-art-527853c19ba5426ea06a256fcfefe724 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-527853c19ba5426ea06a256fcfefe7242025-02-03T01:05:02ZengWileyJournal of Ophthalmology2090-004X2090-00582020-01-01202010.1155/2020/70924327092432Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in SergipeMarco Valadares0Anne Carolyne Lelis Oliveira Pedroso1Alessandro Santana2Angela Maria da Silva3Isabela Soares Costa4Maria Luiza Doria Almeida5Roque Pacheco de Almeida6Department of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilDepartment of Medicine, Federal University of Sergipe, Sergipe 49060-100, BrazilThis study aims at identifying ocular findings in infants with microcephaly associated with presumed intrauterine infection by ZIKV. A cross-sectional study included 62 outpatient infants with congenital microcephaly, presumably secondary to maternal ZIKV infection. The included infants had head circumference below −2 standard deviations, with negative maternal serology for toxoplasmosis, rubella, cytomegalovirus, syphilis, and HIV. Assessment of ocular alterations was performed through review of their medical records. Forty two (67.7%) of the children analyzed presented some degree of ocular alteration. Findings in the posterior segment occurred in 29 (46.8%) patients, including atrophy of the retinal pigmentary epithelium in 15 (24.2%) patients, chorioretinal scars in 14 (22.6%) patients, retinal coloboma in 6 (9.7%) patients, and punctate retinal hemorrhage in 1 (1.6%) patient. Other ocular alterations were seen in 15 (24.2%) patients, including pathological strabismus in 11 (17.7%) patients, congenital cataracts in 2 (3.2%) patients, and nystagmus in 2 (3.2%) patients. Functional alterations were seen in four (6.5%) children. More than one change occurred in 11 (17.7%) children, eight of whom had head circumferences below −3 standard deviations. Changes in both the eyes occurred in 22 (35.5%) children, while 20 (32.3%) children had unilateral involvement. Among the 42 children with any ocular alteration, 27 (64.3%) children presented with severe microcephaly (head circumference with standard deviation lower than −3). The majority of children with microcephaly, presumably secondary to maternal ZIKV infection, present ocular alterations, with a higher frequency of involvement in the fundus. Severe ocular alterations are related to severe microcephaly.http://dx.doi.org/10.1155/2020/7092432 |
| spellingShingle | Marco Valadares Anne Carolyne Lelis Oliveira Pedroso Alessandro Santana Angela Maria da Silva Isabela Soares Costa Maria Luiza Doria Almeida Roque Pacheco de Almeida Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe Journal of Ophthalmology |
| title | Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe |
| title_full | Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe |
| title_fullStr | Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe |
| title_full_unstemmed | Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe |
| title_short | Ocular Findings in Infants with Microcephaly Caused by Presumed Congenital Infection by Zika Virus in Sergipe |
| title_sort | ocular findings in infants with microcephaly caused by presumed congenital infection by zika virus in sergipe |
| url | http://dx.doi.org/10.1155/2020/7092432 |
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