Metabolomics combined with metagenomics analysis reveals the potential mechanism of Zhejiang psyllium polysaccharides against hyperuricemia in rats

Metabolomics combined with metagenomics analysis reveals the potential mechanism of Zhejiang psyllium polysaccharides against hyperuricemia in rats

Abstract This study aimed to assess the anti-hyperuricemia efficacy of Zhejiang psyllium polysaccharides (ZPP) in rats and to explore its underlying mechanism. Hyperuricemia was induced by intragastric administration of potassium oxonate, hypoxanthine, and adenine. The serum levels of uric acid (UA)...

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Main Authors: Dan Wu, Jingjie Niu, Jianping Hu, Hao Wang, Haixue Kuang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Zhejiang psyllium
Polysaccharide
Hyperuricemia
Metabolomics
Metagenomics
Online Access:https://doi.org/10.1038/s41598-025-09048-1
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https://doi.org/10.1038/s41598-025-09048-1

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