Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume

Depressive symptoms in older adults are associated with changes in stress-related markers, functional connectivity and brain volume

Abstract Background Subclinical depressive symptoms increase the risk of developing Alzheimer’s disease (AD). The neurobiological mechanisms underlying this link may involve stress system dysfunction, notably related to the hippocampus which is particularly sensitive to AD. We aimed to investigate t...

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Main Authors: Edelweiss Touron, Robin de Flores, Laurent Coulbault, Cassandre Palix, Anne Chocat, Elizabeth Kuhn, Brigitte Landeau, Florence Mézenge, Daniel Roquet, Léa Chauveau, Sacha Haudry, Denis Vivien, Vincent de La Sayette, Natalie L. Marchant, Gaël Chételat, Géraldine Poisnel, for the Medit-Ageing Research Group
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Depressive symptoms
Aging
Cortisol
Catecholamines
Hypothalamus
Hippocampal subfields
Online Access:https://doi.org/10.1186/s13195-024-01643-0
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https://doi.org/10.1186/s13195-024-01643-0

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