Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis

Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c‐Jun pathway in adaptive resistance to drug‐induced apoptosis

Abstract Drugs that inhibit RAF/MEK signaling, such as vemurafenib, elicit profound but often temporary anti‐tumor responses in patients with BRAFV600E melanoma. Adaptive responses to RAF/MEK inhibition occur on a timescale of hours to days, involve homeostatic responses that reactivate MAP kinase s...

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Bibliographic Details
Main Authors: Mohammad Fallahi‐Sichani, Nathan J Moerke, Mario Niepel, Tinghu Zhang, Nathanael S Gray, Peter K Sorger
Format: Article
Language:English
Published: Springer Nature 2015-03-01
Series:Molecular Systems Biology
Subjects:
adaptive responses
BRAFV600E melanomas
cell‐to‐cell variability
RAF and MEK inhibitors
submaximal drug effect
Online Access:https://doi.org/10.15252/msb.20145877
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https://doi.org/10.15252/msb.20145877

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