Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

G protein-coupled receptors (GPCRs) are integral membrane proteins which closely interact with their plasma membrane lipid microenvironment. Cholesterol is a lipid enriched at the plasma membrane with pivotal roles in the control of membrane fluidity and maintenance of membrane microarchitecture, di...

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Bibliographic Details
Main Authors: Affiong Ika Oqua, Kin Chao, Liliane El Eid, Lisa Casteller, Billy P Baxter, Alba Miguéns-Gómez, Sebastian Barg, Ben Jones, Jorge Bernardino de la Serna, Sarah L Rouse, Alejandra Tomas
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
Subjects:
MD simulations
incretins
islets
GLP-1R
cholesterol
type 2 diabetes
Online Access:https://elifesciences.org/articles/101011
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https://elifesciences.org/articles/101011

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