Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism

Nobiletin restores the intestinal barrier of HFD-induced obese mice by promoting MHC-II expression and lipid metabolism

Abstract The incidence of obesity is increasing annually worldwide. A high-fat diet (HFD) causes intestinal barrier damage, but effective interventions are currently unavailable. Our previous work demonstrated the therapeutic effect of nobiletin on obese mice; thus, we hypothesized that nobiletin co...

Full description

Saved in:
Bibliographic Details
Main Authors: Ni Yang, Yue-Shan Pang, Yali Zheng, Yan-Ju Gong, Wei-Jun Ding
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
High-fat diet (HFD)
Nobiletin
Intestinal barrier
Major histocompatibility complex class-II (MHC-II)
Lipid metabolism
Online Access:https://doi.org/10.1186/s10020-025-01072-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s10020-025-01072-1

Similar Items