Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization

Light Chain Isotype and Antibody-Specificity Impact on Virus Neutralization

Therapeutic antibodies with lambda light chains (λ-Abs) are underrepresented compared to kappa light chains (κ-Abs). Here, we evaluated two SARS-CoV-2-specific monoclonal antibodies (mAbs) that exhibit high (P5C3) and low (H4) antigen binding as κ and λ variants. mAbs expressed in glycoengineered &l...

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Bibliographic Details
Main Authors: Lin Sun, Roman Palt, Georg Schütz, Esther Föderl-Höbenreich, Laura Brod, Antonia Hermle, Anja Lux, Herta Steinkellner, Somanath Kallolimath
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Antibodies
Subjects:
kappa–lambda light chain
monoclonal antibodies
SARS-CoV-2
Fcγ-receptor binding
virus neutralization
stability
Online Access:https://www.mdpi.com/2073-4468/14/2/50
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https://www.mdpi.com/2073-4468/14/2/50

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