Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease

Abstract Alzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the neocortex and hippocampus. Current therapeutic interventions focus on the early stage of AD but lack effective treatment for the late stage of AD, largely due to the inability...

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Bibliographic Details
Main Authors: Zheng Wu, Liang Xu, Yu Xie, Abhijeet Sambangi, Shreya Swaminathan, Zifei Pei, Wenyu Ji, Zeru Li, Yaowei Guo, Zhifei Li, Gong Chen
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
Alzheimer's disease
gene therapy
neurodegeneration
NeuroD1
Online Access:https://doi.org/10.1002/advs.202410080
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https://doi.org/10.1002/advs.202410080

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