Inhibition of dimeric SARS-CoV-2 Mpro displays positive cooperativity and a mixture of covalent and non-covalent binding

Inhibition of dimeric SARS-CoV-2 Mpro displays positive cooperativity and a mixture of covalent and non-covalent binding

Summary: SARS-CoV-2 Mpro is a cysteine protease that acts as a symmetrical dimer and displays positive cooperativity for substrate turnover. A series of potent reversible covalent peptidomimetic aldehydes and nitriles was designed as Mpro inhibitors. To better understand the observed structure activ...

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Main Authors: Krishna M. Padmanabha Das, Jun Chen, Paul S. Charifson, Jeremy Green, Henry Tang, Sanjay Panchal, Fan Pu, Alla Korepanova, Abhinav Dubey, Gustavo Afanador, Vladimir Stojkovic, Boguslaw Nocek, Lance Bigelow, Sarah H. Stubbs, Robert A. Davey, David A. DeGoey, Haribabu Arthanari, Mark N. Namchuk
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:iScience
Subjects:
Biochemistry
Immunology
Virology
Structural biology
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422501034X
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