Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling

Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling

Introduction: High palmitic acid (PA) levels trigger metainflammation, facilitating the onset and progression of chronic metabolic diseases. Recently, exosomes were identified as new inflammation mediators. However, the mechanism by which macrophage exosomes mediate PA-induced inflammation remains u...

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Main Authors: Huiyu Luo, Jiexian Wang, Fengjuan Lin, Yuguo Liu, Xinglong Wu, Gan Li, Chuhong Su, Junbin Chen, Fei Xiong, Jiaqi Mo, Zhongdaixi Zheng, Xiangyi Zheng, Qing Li, Longying Zha
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Journal of Advanced Research
Subjects:
Exosomes
Macrophage
Metainflammation
IκBα
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224002613
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