MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume
Abstract Idiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive...
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| Format: | Article |
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Nature Portfolio
2024-12-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-024-00843-7 |
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| author | Marina Campins-Romeu Rebeca Conde-Sardón Isabel Sastre-Bataller Carlos Morata-Martínez Mireya Losada-López José Luís León-Guijarro Luis Raga-Rodríguez Julia Pérez-García Antonio Gutiérrez-Martín Andrés M. Lozano Raquel Baviera-Muñoz Irene Martínez-Torres |
| author_facet | Marina Campins-Romeu Rebeca Conde-Sardón Isabel Sastre-Bataller Carlos Morata-Martínez Mireya Losada-López José Luís León-Guijarro Luis Raga-Rodríguez Julia Pérez-García Antonio Gutiérrez-Martín Andrés M. Lozano Raquel Baviera-Muñoz Irene Martínez-Torres |
| author_sort | Marina Campins-Romeu |
| collection | DOAJ |
| description | Abstract Idiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion. Between June 2021 and October 2023, twelve PD patients underwent the procedure, with primary outcomes focused on safety and motor improvements after six months. Results indicated significant motor improvements, with over 50% reduction in tremor, rigidity, and bradykinesia, while balance and gait remained stable. Quality of life also improved. Side effects were generally mild and transient, though some patients experienced involuntary movements, managed through medication adjustments. Despite limitations, this technique appears to offer a promising, less-invasive alternative for managing PD symptoms with a favorable risk-benefit profile. Further research is necessary to refine the procedure and assess long-term outcomes. |
| format | Article |
| id | doaj-art-5208d520273d438892bd0ff8101734bd |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-5208d520273d438892bd0ff8101734bd2025-02-02T12:13:43ZengNature Portfolionpj Parkinson's Disease2373-80572024-12-011011910.1038/s41531-024-00843-7MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion VolumeMarina Campins-Romeu0Rebeca Conde-Sardón1Isabel Sastre-Bataller2Carlos Morata-Martínez3Mireya Losada-López4José Luís León-Guijarro5Luis Raga-Rodríguez6Julia Pérez-García7Antonio Gutiérrez-Martín8Andrés M. Lozano9Raquel Baviera-Muñoz10Irene Martínez-Torres11Movement Disorders Unit, Department of Neurology, Hospital La FeUnit of Functional Neurosurgery, Department of Neurosurgery, Hospital La FeMovement Disorders Unit, Department of Neurology, Hospital La FeMovement Disorders Unit, Department of Neurology, Hospital La FeAscires Biomedical GroupAscires Biomedical GroupResearch Group in Alzheimer Disease, Hospital La Fe Health Research InstituteMovement Disorders Unit, Department of Neurology, Hospital La FeUnit of Functional Neurosurgery, Department of Neurosurgery, Hospital La FeAscires Biomedical GroupMovement Disorders Unit, Department of Neurology, Hospital La FeMovement Disorders Unit, Department of Neurology, Hospital La FeAbstract Idiopathic Parkinson’s Disease (PD) is a neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and postural instability. Magnetic Resonance-guided high-intensity focused ultrasound (MRgFUS) of the subthalamic nucleus (STN) is gaining recognition as a minimally invasive surgical option. This study assesses the safety and efficacy of unilateral MRgFUS subthalamotomy, aiming to create the smallest effective lesion. Between June 2021 and October 2023, twelve PD patients underwent the procedure, with primary outcomes focused on safety and motor improvements after six months. Results indicated significant motor improvements, with over 50% reduction in tremor, rigidity, and bradykinesia, while balance and gait remained stable. Quality of life also improved. Side effects were generally mild and transient, though some patients experienced involuntary movements, managed through medication adjustments. Despite limitations, this technique appears to offer a promising, less-invasive alternative for managing PD symptoms with a favorable risk-benefit profile. Further research is necessary to refine the procedure and assess long-term outcomes.https://doi.org/10.1038/s41531-024-00843-7 |
| spellingShingle | Marina Campins-Romeu Rebeca Conde-Sardón Isabel Sastre-Bataller Carlos Morata-Martínez Mireya Losada-López José Luís León-Guijarro Luis Raga-Rodríguez Julia Pérez-García Antonio Gutiérrez-Martín Andrés M. Lozano Raquel Baviera-Muñoz Irene Martínez-Torres MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume npj Parkinson's Disease |
| title | MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume |
| title_full | MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume |
| title_fullStr | MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume |
| title_full_unstemmed | MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume |
| title_short | MRgFUS subthalamotomy in Parkinson’s disease: an approach aimed at minimizing Lesion Volume |
| title_sort | mrgfus subthalamotomy in parkinson s disease an approach aimed at minimizing lesion volume |
| url | https://doi.org/10.1038/s41531-024-00843-7 |
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