Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system

Developmental and physiological impacts of pathogenic human huntingtin protein in the nervous system

Huntington's Disease (HD) is a neurodegenerative disorder, part of the nine identified inherited polyglutamine (polyQ) diseases. Most commonly, HD pathophysiology manifests in middle-aged adults with symptoms including progressive loss of motor control, cognitive decline, and psychiatric distur...

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Main Authors: Tadros A. Hana, Veronika G. Mousa, Alice Lin, Rawan N. Haj-Hussein, Andrew H. Michael, Madona N. Aziz, Sevinch U. Kamaridinova, Sabita Basnet, Kiel G. Ormerod
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Neurobiology of Disease
Subjects:
Drosophila
Huntington's disease
Organelle trafficking
Neuromuscular junction
Aggregation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003346
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