Molecular docking, drug-likeness properties, and toxicity prediction of alkaloidal phytoconstituents of piper longum against monoamine oxidase enzyme-A as an anti-depressive agent

Molecular docking, drug-likeness properties, and toxicity prediction of alkaloidal phytoconstituents of piper longum against monoamine oxidase enzyme-A as an anti-depressive agent

Abstract Background Depression is a multifaceted disorder characterized by dysregulation of the immune system, the hypothalamic–pituitary–adrenal (HPA) axis, neurotransmitter levels, and the neurotrophic system. Globally, it impacts approximately 280 million individuals. Although synthetic medicatio...

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Main Authors: Santosh Prasad Chaudhary kurmi, Shankar Thapa, Somashekhar M. Metri, Mahalakshmi Suresha Biradar, V. Angelin Esther, Ashok Kumar Murav, Sharvendra Nath Maurya
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Discover Chemistry
Subjects:
Depression
Monoamine oxidase
Piper longum
Molecular docking
Online Access:https://doi.org/10.1007/s44371-025-00188-x
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https://doi.org/10.1007/s44371-025-00188-x

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