The C. elegans CHP1 homolog, pbo-1, functions in innate immunity by regulating the pH of the intestinal lumen.

Caenorhabditis elegans are soil-dwelling nematodes and models for understanding innate immunity and infection. Previously, we developed a novel fluorescent dye (KR35) that accumulates in the intestine of C. elegans and reports a dynamic wave in intestinal pH associated with the defecation motor prog...

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Bibliographic Details
Main Authors: Saida Benomar, Patrick Lansdon, Aaron M Bender, Blake R Peterson, Josephine R Chandler, Brian D Ackley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1008134&type=printable
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