Long-Term Immune Consequences of Initial SARS-CoV-2 A.23.1 Exposure: A Longitudinal Study of Antibody Responses and Cross-Neutralization in a Ugandan Cohort

Long-Term Immune Consequences of Initial SARS-CoV-2 A.23.1 Exposure: A Longitudinal Study of Antibody Responses and Cross-Neutralization in a Ugandan Cohort

<b>Background:</b> This study assessed the long-term dynamics of neutralizing antibodies in a Ugandan cohort primarily exposed to the A.23.1 SARS-CoV-2 variant, examining how this shaped immune breadth and potency against diverse strains following infection and prototype-based vaccinatio...

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Bibliographic Details
Main Authors: Gerald Kevin Oluka, Jackson Sembera, Joseph Ssebwana Katende, Violet Ankunda, Laban Kato, Ashwini Kurshan, Carl Graham, Jeffrey Seow, Katie J. Doores, Michael H. Malim, Julie M. Fox, Pontiano Kaleebu, Jennifer Serwanga
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
immune imprinting
SARS-CoV-2 A.23.1 variant
cross-neutralization
antibody dynamics
neutralizing titers
antigenic surveillance
Online Access:https://www.mdpi.com/2076-393X/13/2/143
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https://www.mdpi.com/2076-393X/13/2/143

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