The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters
The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2018/7041342 |
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| author | Monika Walankiewicz Ewelina Grywalska Grzegorz Polak Izabela Korona-Glowniak Elzbieta Witt Agata Surdacka Jan Kotarski Jacek Rolinski |
| author_facet | Monika Walankiewicz Ewelina Grywalska Grzegorz Polak Izabela Korona-Glowniak Elzbieta Witt Agata Surdacka Jan Kotarski Jacek Rolinski |
| author_sort | Monika Walankiewicz |
| collection | DOAJ |
| description | The cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. The expression of PD-1 and its ligand (PD-L1) may contribute to continuous T cell activation and development of inflammation and injury of the tissue. To our knowledge, this is the first study evaluating frequencies of PD-1-positive T CD3+ cells (CD4+ and CD8+) and B cells (CD19+) in patients with endometriosis. Peripheral blood (PB) samples from 25 female patients and 20 healthy age and sex-matched subjects serving as controls were used in the study. Using flow cytometric analysis, we assessed the differences in the frequencies of PD-1-positive T and B lymphocytes in the study group and healthy individuals. Alteration of the PD-1/PD-L1 axis may contribute to the pathogenesis of endometriosis, as patients with advanced disease are characterized by higher frequencies of PD-1-positive T and B cells. Expression of PD-1 and PD-L1 on T and B cells could represent the hallmark of immune system reaction to chronic antigenic exposition in patients with endometriosis. |
| format | Article |
| id | doaj-art-519b00a74ac844d7a2118b0ac73119c9 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-519b00a74ac844d7a2118b0ac73119c92025-02-03T01:21:16ZengWileyMediators of Inflammation0962-93511466-18612018-01-01201810.1155/2018/70413427041342The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory ParametersMonika Walankiewicz0Ewelina Grywalska1Grzegorz Polak2Izabela Korona-Glowniak3Elzbieta Witt4Agata Surdacka5Jan Kotarski6Jacek Rolinski7I Department of Gynecology, Medical University of Lublin, 16 Staszica Street, 20-081 Lublin, PolandDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, PolandI Department of Gynecology, Medical University of Lublin, 16 Staszica Street, 20-081 Lublin, PolandDepartment of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin, 1 Chodzki Street, 20-093 Lublin, PolandAugusta Kliniken Bochum, 26 Bergstrasse Street, 44791 Bochum, GermanyDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, PolandI Department of Gynecology, Medical University of Lublin, 16 Staszica Street, 20-081 Lublin, PolandDepartment of Clinical Immunology and Immunotherapy, Medical University of Lublin, 4a Chodzki Street, 20-093 Lublin, PolandThe cause of endometriosis remains unknown. However, studies investigating the link between this condition and the immune system revealed several immunological abnormalities focused on cell-mediated immunity. As a major immune checkpoint, programmed cell death protein 1 (PD-1) displays an important inhibitory function in the maintenance of peripheral tolerance. The expression of PD-1 and its ligand (PD-L1) may contribute to continuous T cell activation and development of inflammation and injury of the tissue. To our knowledge, this is the first study evaluating frequencies of PD-1-positive T CD3+ cells (CD4+ and CD8+) and B cells (CD19+) in patients with endometriosis. Peripheral blood (PB) samples from 25 female patients and 20 healthy age and sex-matched subjects serving as controls were used in the study. Using flow cytometric analysis, we assessed the differences in the frequencies of PD-1-positive T and B lymphocytes in the study group and healthy individuals. Alteration of the PD-1/PD-L1 axis may contribute to the pathogenesis of endometriosis, as patients with advanced disease are characterized by higher frequencies of PD-1-positive T and B cells. Expression of PD-1 and PD-L1 on T and B cells could represent the hallmark of immune system reaction to chronic antigenic exposition in patients with endometriosis.http://dx.doi.org/10.1155/2018/7041342 |
| spellingShingle | Monika Walankiewicz Ewelina Grywalska Grzegorz Polak Izabela Korona-Glowniak Elzbieta Witt Agata Surdacka Jan Kotarski Jacek Rolinski The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters Mediators of Inflammation |
| title | The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters |
| title_full | The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters |
| title_fullStr | The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters |
| title_full_unstemmed | The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters |
| title_short | The Increase of Circulating PD-1- and PD-L1-Expressing Lymphocytes in Endometriosis: Correlation with Clinical and Laboratory Parameters |
| title_sort | increase of circulating pd 1 and pd l1 expressing lymphocytes in endometriosis correlation with clinical and laboratory parameters |
| url | http://dx.doi.org/10.1155/2018/7041342 |
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