Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein

Identification of lurasidone as a potent inhibitor of severe fever with thrombocytopenia syndrome virus by targeting the viral nucleoprotein

IntroductionSevere fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus that causes acute febrile illness with thrombocytopenia and a high mortality rate in humans. Currently, no specific antiviral agents have been approved for the prevention or treatment of SFTSV...

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Bibliographic Details
Main Authors: Ting Cheng, Qingcui Xiao, Jing Cui, Shuangjie Dong, Yuqin Wu, Wenqiang Li, Xinya Yang, Lina Ma, Zhiyong Li, Peng Sun, Yinli Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Microbiology
Subjects:
SFTSV
antiviral drugs
molecular docking
nucleoprotein
lurasidone
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1578844/full
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https://www.frontiersin.org/articles/10.3389/fmicb.2025.1578844/full

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