Down-regulation of neuroprotective protein kinase D in Huntington´s disease

Down-regulation of neuroprotective protein kinase D in Huntington´s disease

Abstract Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder characterized by the selective dysfunction and loss of neurons in the striatum and cerebral cortex. Experimental evidence suggests that GABAergic medium-sized spiny neurons (MSNs) in the striatum are p...

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Main Authors: Álvaro Sebastián-Serrano, Ana Simón-García, María Santos-Galindo, Marina Prudencio Sánchez-Carralero, Alberto H.-Alcántara, Cristina Clemente, Julia Pose-Utrilla, Miguel R. Campanero, Eva Porlan, José J. Lucas, Teresa Iglesias
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07688-9
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https://doi.org/10.1038/s41419-025-07688-9

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