Melatonin mediates the BMP4/MAPK signaling pathway to alleviate zearalenone-induced abnormal embryonic development in mice

Melatonin mediates the BMP4/MAPK signaling pathway to alleviate zearalenone-induced abnormal embryonic development in mice

Zearalenone (ZEA) is a common mycotoxin found in crops that poses a threat to human health, particularly the female reproductive system. Here, we show that exposing mouse zygotes to ZEA in vitro significantly impairs embryo development, leading to embryo arrest. Remarkably, treatment of ZEA-exposed...

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Bibliographic Details
Main Authors: Mengyao Wang, Zhixin Pu, Jing Zhang, Peiwen Wang, Yaxin Chen, Yating Zhu, Hongzhen Ruan, Dongmei Ji, Weiwei Zou, Huiru Cheng, Zhiming Ding, Yunxia Cao, Yajing Liu, Dan Liang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Zearalenone
Embryo development
Melatonin
Bone morphogenetic protein 4
Mitogen-activated protein kinase
Online Access:http://www.sciencedirect.com/science/article/pii/S014765132500404X
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