Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis

Gamma -aminobutyric acid ameliorates neurological impairments in type 1 diabetes mellitus mice by regulating the “gut flora-LPS-TLR4-NF-ΚB” signalling Axis

Abstract This study examined the potential impact of gamma-aminobutyric acid (GABA) supplementation on the progression of type 1 diabetes mellitus (T1DM) through alterations in gut flora and its associated effects on neurological functions. A T1DM mouse model was created using streptozotocin. The st...

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Bibliographic Details
Main Authors: Jiao Wang, Lihai Zhang, Xianhe Wang, Jing Dong, Jiaxin Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Type 1 diabetes mellitus
Intestinal flora
GABA
Neurological impairments
LPS
TLR4-NF-κB
Online Access:https://doi.org/10.1186/s13098-025-01752-2
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https://doi.org/10.1186/s13098-025-01752-2

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