Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites in mice

Androgens inhibit protective CD8+ T cell responses against pre-erythrocytic malaria parasites in mice

Abstract Attenuated whole organism vaccines targeting the malaria liver stage reliably confer sterile immunity. These vaccines completely protect female mice from infection, but protection in male mice remains unproven. We discover that male mice vaccinated with prime-and-trap, a whole organism-base...

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Main Authors: Caroline J. Duncombe, Nilasha Sen, Felicia N. Watson, Alen S. Poehlman, Erik D. Layton, Kenneth Boey, Ethan N. Conrad, Anya C. Kalata, A. Mariko Seilie, Kimberly A. Dill-McFarland, Chetan Seshadri, Melanie J. Shears, Sean C. Murphy
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60193-7
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https://doi.org/10.1038/s41467-025-60193-7

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