Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS

Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS

Abstract, Whether early exposure to general anesthetics hurts human brain development is still under discussion. Animal studies have documented multiple neurotoxicities of repeated/prolonged exposure to sevoflurane (Sev, a commonly used pediatric anesthetic) at the neonatal stage. Its effects on hum...

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Main Authors: Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rougang Xie, Honghui Mao, Boyang Ren, Bosong Huang, Changhong Shi, Zhicheng Shao, Shengxi Wu, Yazhou Wang, Hui Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01425-0
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https://doi.org/10.1038/s12276-025-01425-0

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