Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods.

Penalised regression improves imputation of cell-type specific expression using RNA-seq data from mixed cell populations compared to domain-specific methods.

Gene expression studies often use bulk RNA sequencing of mixed cell populations because single cell or sorted cell sequencing may be prohibitively expensive. However, mixed cell studies may miss expression patterns that are restricted to specific cell populations. Computational deconvolution can be...

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Main Authors: Wei-Yu Lin, Melissa Kartawinata, Bethany R Jebson, Restuadi Restuadi, Hannah Peckham, Anna Radziszewska, Claire T Deakin, Coziana Ciurtin, CLUSTER Consortium, Lucy R Wedderburn, Chris Wallace
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-03-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1012859
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https://doi.org/10.1371/journal.pcbi.1012859

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