Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir

Thymidine Analogue Mutations with M184V Significantly Decrease Phenotypic Susceptibility of HIV-1 Subtype C Reverse Transcriptase to Islatravir

Islatravir (ISL) is the first-in-class nucleoside reverse transcriptase translocation inhibitor (NRTtI) with novel modes of action. Data on ISL resistance are currently limited, particularly to HIV-1 non-B subtypes. This study aimed to assess prevalent nucleos(t)ide reverse transcriptase inhibitor (...

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Bibliographic Details
Main Authors: Hyeonah Byun, Maria Antonia Papathanasopoulos, Kim Steegen, Adriaan Erasmus Basson
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Viruses
Subjects:
HIV
antiretroviral therapy (ART)
antiviral drugs
NRTI
islatravir (ISL)
phenotypic
Online Access:https://www.mdpi.com/1999-4915/16/12/1888
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