Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance

Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance

Abstract Background Doxorubicin (DOX) demonstrates significant therapeutic and anticancer efficacy. Nevertheless, it demonstrates significant cardiotoxicity, resulting in permanent cardiac damage. Ligustrazine (LIG) is a bioactive alkaloid derived from the rhizome of the medicinal plant Ligusticum c...

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Bibliographic Details
Main Authors: Junyan Wang, Haowen Zhuang, Chun Li, Ruiqi Cai, Hongshuo Shi, Boxian Pang, Zhijiang Guo, Sang-Bing Ong, Yifeng Nie, Yingzhen Du, Hao Zhou, Xing Chang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Nanobiotechnology
Subjects:
Ligustrazine
Nano-carrier drug delivery
Doxorubicin-induced myocardial injury
Piezo-type mechanosensitive ion channel component 1
Prohibitin 2
Mitochondrial quality control
Online Access:https://doi.org/10.1186/s12951-025-03420-z
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https://doi.org/10.1186/s12951-025-03420-z

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