Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D

Structural comparison of substrate-binding pockets of serine β-lactamases in classes A, C, and D

β-lactams have been the most successful antibiotics, but the rise of multi-drug resistant (MDR) bacteria threatens their effectiveness. Serine β-lactamases (SBLs), among the most common causes of resistance, are classified as A, C, and D, with numerous variants complicating structural and substrate...

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Bibliographic Details
Main Authors: Hyeonmin Lee, Hyunjae Park, Kiwoong Kwak, Chae-eun Lee, Jiwon Yun, Donghyun Lee, Jung Hun Lee, Sang Hee Lee, Lin-Woo Kang
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
serine β-lactamase (SBL)
β-lactams
substrate spectrum
antibiotic resistance
substrate-binding pocket (SBP)
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2024.2435365
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https://www.tandfonline.com/doi/10.1080/14756366.2024.2435365

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