Lipid peroxidation triggered by the degradation of xCT contributes to gasdermin D-mediated pyroptosis in COPD

Background: Pyroptosis is an inflammatory form of regulated necrosis that has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the role of lipid peroxidation in pyroptosis and its underlying mechanisms in COPD remain unclear. Methods: In vitro, human bron...

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Bibliographic Details
Main Authors: Tianhua Hou, Laiyu Zhu, Yan Zhang, Ying Tang, Yun Gao, Shucheng Hua, Xinxin Ci, Liping Peng
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Redox Biology
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Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724003665
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