Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels
Seropositivity study of Varicella in Healthy Populations in Guangzhou, China. Infection with varicella-zoster virus (VZV) leads to skin and mucous membranes blisters and the complications can be life threatening. A seroepidemiological study conducted from 2020 to 2022 in Guangzhou, China, aimed to e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/13/1/23 |
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| author | Qing He Yang Xu Yilan Li Pinting Zhu Lei Luo |
| author_facet | Qing He Yang Xu Yilan Li Pinting Zhu Lei Luo |
| author_sort | Qing He |
| collection | DOAJ |
| description | Seropositivity study of Varicella in Healthy Populations in Guangzhou, China. Infection with varicella-zoster virus (VZV) leads to skin and mucous membranes blisters and the complications can be life threatening. A seroepidemiological study conducted from 2020 to 2022 in Guangzhou, China, aimed to evaluate varicella antibody levels. We measured varicella antibody concentrations using an enzyme-linked immunosorbent assay. A total of 3300 people were enrolled in the study. The mean varicella antibody level was 171.2 mIU/mL (95% CI: 158.9, 184.4), with an overall positivity rate of 67.00% (95% CI: 65.37, 68.60). The mean level of those positive subjective was 581.2 mIU/mL (95% CI: 552.3, 611.5). Varicella antibody levels were found to be influenced by age, vaccination dosage, and history of varicella infection. Antibody level increased with age and the number of vaccinations. The antibody induced by the varicella vaccine remained at protective levels for at least 6 years post-vaccination. We recommend two doses of the varicella vaccine for both children and adults and the integration of the varicella vaccine into the national routine immunization program. |
| format | Article |
| id | doaj-art-50f333a1ce78484db19284692e9c0d82 |
| institution | Kabale University |
| issn | 2076-393X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj-art-50f333a1ce78484db19284692e9c0d822025-01-24T13:51:41ZengMDPI AGVaccines2076-393X2024-12-011312310.3390/vaccines13010023Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody LevelsQing He0Yang Xu1Yilan Li2Pinting Zhu3Lei Luo4Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaGuangzhou Center for Disease Control and Prevention, Guangzhou 510440, ChinaSeropositivity study of Varicella in Healthy Populations in Guangzhou, China. Infection with varicella-zoster virus (VZV) leads to skin and mucous membranes blisters and the complications can be life threatening. A seroepidemiological study conducted from 2020 to 2022 in Guangzhou, China, aimed to evaluate varicella antibody levels. We measured varicella antibody concentrations using an enzyme-linked immunosorbent assay. A total of 3300 people were enrolled in the study. The mean varicella antibody level was 171.2 mIU/mL (95% CI: 158.9, 184.4), with an overall positivity rate of 67.00% (95% CI: 65.37, 68.60). The mean level of those positive subjective was 581.2 mIU/mL (95% CI: 552.3, 611.5). Varicella antibody levels were found to be influenced by age, vaccination dosage, and history of varicella infection. Antibody level increased with age and the number of vaccinations. The antibody induced by the varicella vaccine remained at protective levels for at least 6 years post-vaccination. We recommend two doses of the varicella vaccine for both children and adults and the integration of the varicella vaccine into the national routine immunization program.https://www.mdpi.com/2076-393X/13/1/23varicellaseroepidemiologyvaccination |
| spellingShingle | Qing He Yang Xu Yilan Li Pinting Zhu Lei Luo Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels Vaccines varicella seroepidemiology vaccination |
| title | Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels |
| title_full | Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels |
| title_fullStr | Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels |
| title_full_unstemmed | Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels |
| title_short | Optimizing Varicella Vaccination Strategy: A Study on Age and Dose Impacts on Antibody Levels |
| title_sort | optimizing varicella vaccination strategy a study on age and dose impacts on antibody levels |
| topic | varicella seroepidemiology vaccination |
| url | https://www.mdpi.com/2076-393X/13/1/23 |
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