A drug-drug co-amorphous system for highly improved solubility of breviscapine: an experimental and computational study

A drug-drug co-amorphous system for highly improved solubility of breviscapine: an experimental and computational study

Abstract Drug-drug co-amorphous systems are a promising approach to improve the aqueous solubility of poorly water-soluble drugs. This study explores the combination of breviscapine (BRE) and matrine (MAT) form an amorphous salt, aiming to synergistically enhance the solubility and dissolution of BR...

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Bibliographic Details
Main Authors: Zhi Dong, Wenbin Jin, Jiao Wang, Huiyun Yin, Yan Ma, Xixi Hu, Jiali Wang, Chen Liu, Wenping Wang
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Intermolecular interaction
Co-amorphous system
Salt formation
Solubility enhancement
Brevascapine
Matrine
Online Access:https://doi.org/10.1038/s41598-024-82524-2
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https://doi.org/10.1038/s41598-024-82524-2

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