SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN
Methods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/429 |
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| author | A. Z. Abyshev I. K. Zhurkovich D. Yu. Ivkin C. B. Nguyen |
| author_facet | A. Z. Abyshev I. K. Zhurkovich D. Yu. Ivkin C. B. Nguyen |
| author_sort | A. Z. Abyshev |
| collection | DOAJ |
| description | Methods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by determining prothrombin time (PT). The most pronounced activity was possessed by substances AZ-5 (conjugate warfarin with a fragment of the substance diumancal, 41,2±2,3 s) and AZ-9 (diumancal, 45,18±4,85 s), comparable with the reference drug warfarin (37,4±2,8 s). |
| format | Article |
| id | doaj-art-50cc7c135d3c4ffabc7da1fe003b3d94 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-50cc7c135d3c4ffabc7da1fe003b3d942025-08-20T02:54:18ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102192198429SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARINA. Z. Abyshev0I. K. Zhurkovich1D. Yu. Ivkin2C. B. Nguyen3Saint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of HealthcareInstitute of Toxicology FMBASaint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of HealthcareSaint-Petersburg State Chemical-Pharmaceutical Academy, Ministry of HealthcareMethods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by determining prothrombin time (PT). The most pronounced activity was possessed by substances AZ-5 (conjugate warfarin with a fragment of the substance diumancal, 41,2±2,3 s) and AZ-9 (diumancal, 45,18±4,85 s), comparable with the reference drug warfarin (37,4±2,8 s).https://www.pharmjournal.ru/jour/article/view/429coumarinwarfarindiumancalanticoagulant activity |
| spellingShingle | A. Z. Abyshev I. K. Zhurkovich D. Yu. Ivkin C. B. Nguyen SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN Разработка и регистрация лекарственных средств coumarin warfarin diumancal anticoagulant activity |
| title | SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN |
| title_full | SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN |
| title_fullStr | SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN |
| title_full_unstemmed | SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN |
| title_short | SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN |
| title_sort | synthesis physico chemical analysis and pharmacological activity of some derivatives of warfarin |
| topic | coumarin warfarin diumancal anticoagulant activity |
| url | https://www.pharmjournal.ru/jour/article/view/429 |
| work_keys_str_mv | AT azabyshev synthesisphysicochemicalanalysisandpharmacologicalactivityofsomederivativesofwarfarin AT ikzhurkovich synthesisphysicochemicalanalysisandpharmacologicalactivityofsomederivativesofwarfarin AT dyuivkin synthesisphysicochemicalanalysisandpharmacologicalactivityofsomederivativesofwarfarin AT cbnguyen synthesisphysicochemicalanalysisandpharmacologicalactivityofsomederivativesofwarfarin |