SYNTHESIS, PHYSICO-CHEMICAL ANALYSIS AND PHARMACOLOGICAL ACTIVITY OF SOME DERIVATIVES OF WARFARIN
Methods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
| Subjects: | |
| Online Access: | https://www.pharmjournal.ru/jour/article/view/429 |
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| Summary: | Methods of synthesis of 7 warfarin derivatives from which three are combined has been developed. Their structural features, physicochemical properties of synthesized compounds by modern and spectral methods (IR, NMR spectroscopy) were determined. Their anticoagulant activity in vivo were studied by determining prothrombin time (PT). The most pronounced activity was possessed by substances AZ-5 (conjugate warfarin with a fragment of the substance diumancal, 41,2±2,3 s) and AZ-9 (diumancal, 45,18±4,85 s), comparable with the reference drug warfarin (37,4±2,8 s). |
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| ISSN: | 2305-2066 2658-5049 |