PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression and underlying mechanisms remain unclear. In...

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Bibliographic Details
Main Authors:	Xiaomin Wu, Boshi Wang, Yingjian Hou, Yipeng Fang, Yuan Jiang, Yuelei Song, Youyi Liu, Cheng Jin
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Series:	Biomolecules
Subjects:	hepatocellular carcinoma ASIC1 PFKM acidic tumor microenvironment glycolysis cell survival
Online Access:	https://www.mdpi.com/2218-273X/15/3/356
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