PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

PFKM-Mediated Glycolysis: A Pathway for ASIC1 to Enhance Cell Survival in the Acidic Microenvironment of Liver Cancer

The acidic tumor microenvironment plays a critical role in promoting liver cancer cell survival by enhancing glycolysis and adaptive mechanisms. Acid-sensing ion channel 1 (ASIC1) is a key regulator of pH sensing, but its role in liver cancer progression and underlying mechanisms remain unclear. In...

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Bibliographic Details
Main Authors: Xiaomin Wu, Boshi Wang, Yingjian Hou, Yipeng Fang, Yuan Jiang, Yuelei Song, Youyi Liu, Cheng Jin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Biomolecules
Subjects:
hepatocellular carcinoma
ASIC1
PFKM
acidic tumor microenvironment
glycolysis
cell survival
Online Access:https://www.mdpi.com/2218-273X/15/3/356
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